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According to the applicant, the TOPS TM System received Breakthrough Device designation from FDA on October 26, 2020 for patients between 35 and 80 years of age suffering from neurogenic claudication resulting from degenerative spondylolisthesis up to Grade I with moderate to severe lumbar spinal stenosis and either the thickening of the ligamentum flavum or scaring facet joint capsule at one level from L2 to L5

In the design of ADCs, linkers are one of the core elements for achieving precise drug release

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Trachy, R (1988)

Cell Reports (2019) 8

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